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This effect of Rac1 was initially demonstrated in Drosophila (Shuai et al., 2010) where controlled expression of dominant negative and constitutively active Rac1 mutants in the MBs using the Gal/UAS binary system delayed and facilitated aversive olfactory memory decay, respectively, without affecting memory acquisition (Shuai et al., 2010)

doi: 10.1016/j.ejca.2009.08.003

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Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation