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10.1007/s12672-023-00716-0 207

Br J Addict 84:13531357 Perry EC (2014) Inpatient management of acute alcohol withdrawal syndrome

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

Bone marrow lesions can cause discomfort and may accelerate cartilage loss in the knees of OA patients (6467)

Together, they work synergistically to enhance pulsatile GH release, closely mimicking the bodys natural rhythms

Recently announced clinical data for PROTAC ARV-766 showed that this degrader is effective in patients with resistance-conferring mutations in the AR gene and has a good tolerability profile 220,221