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Intriguingly, reduction of fasting plasma BCAAs levels alone is insufficient to improve insulin sensitivity, suggesting a potentially synergistic role of multiple tissues in modulating BCAAs metabolism to alter insulin responsiveness ( 3 Metabolic dysregulation: molecular bridges between DM and pulmonary injury DM creates a pathological environment for multi-organ injury through comprehensive dysregulation of carbohydrate, lipid, and amino acid metabolism

* Correspondence: Feng Luo, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Taketa T, Correa AM, Suzuki A, Blum MA, Lee JH, Welsh J, Lin SH, Maru DM, Erasmus JJ, Bhutani MS, Weston B, Rice DC , Swisher S, Hofstetter WL, Ajani JA