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The emergence of drug-resistant Mtb strains against INH and/or RIF and drug-associated toxicity put forth a significant challenge in treatment (Organization, 2014

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Understanding these separate mechanisms is essential before considering whether combining them sometimes referred to as 'stacking' in online communities could offer any meaningful clinical benefit, and what risks such a combination might carry

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In addition, the copper-dependent transcription factor ATOX1 can be involved in tumor angiogenesis and vascular remodeling by regulating the platelet-derived growth factor (PDGF) signaling pathway (99)