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Current SRMA on CoQ10 therapy by Bakri et al [6], based on subgroup analysis and meta-regression model, attempted to tackle the challenge of heterogeneity of studies

The effect on certain inflammatory biomarkers (TNF- and IL-17) was evident only in subjects with IBS-D, but changes in other inflammatory markers and in those related to oxidative stress were apparent regardless of IBS subtype

Nonetheless, the main modifications in relation to exercise performance seem to be enhanced absorption, delivery, and subsequent oxidation of free fatty acids

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