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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Kashiwabara M., Asano K., Mizuyoshi T., Kobayashi H

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Attempts to produce drugs that can reach the mitochondria in the brain , however, have been rare

To date, three rapalogs are being tested in clinical trials, CCI-779 (temsirolimus), AP23573 or MK-8669 (ridaforolimus), and RAD001 (everolimus) (198)

It does not suppress endogenous hormone production and does not require post-cycle therapy (PCT)