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FIGURE 3 Overall, the ligand-based pharmacophore models present strength in terms of high recall and ROC AUC values, suggesting their potential utility in identifying novel active compounds

Growth/differentiation factor-15 (GDF-15) is a stress-induced cytokine expressed in multiple cell types, including cardiomyocytes, adipocytes, and macrophages

Patients should receive clear instructions regarding symptoms or changes that should prompt immediate medical evaluation, and healthcare providers should maintain heightened vigilance for potential adverse effects

Brain Res 2006;1117:54-60

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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head