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The levels of O-Am and OEA increased, while the levels of the other substances decreased after immunotherapy

However, the transient interaction with IgM is sufficient to deposit sublytic quantities of C3b, an excellent opsonin, which leads to the removal of red cells by phagocytes in the spleen, liver, and bone marrow (extravascular hemolysis)

The main obstacle of such treatments is the necessity of spraying for several consecutive days, which could be overcome by targeted delivery systems

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