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Double-blind, placebo-controlled trial to evaluate the effectiveness of polypodium leucotomos extract in the treatment of melasma in asian skin: a pilot study

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However, when excessive or sustained, inflammatory reactions can paradoxically lead to secondary tissue damage 22

Increased Th2 activity enhances cytokine production, in particular IL-4, IL-5, and IL-13, and decreases IFN- synthesis (143)