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The regulation of these metabolic enzymes not only affects cell survival but is also closely associated with the development of various diseases, including cancer and neurodegenerative disorders ( 4.2 The role of antioxidants in ferroptosis Antioxidants play a crucial role in the regulation of ferroptosis

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In an in-vivo study, it has been seen that mitochondrial ROS can have less detrimental effects in worms by increasing their lifespan while increased level of ROS in cytoplasmic may have less lifespan of worms [43]

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