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A suboptimal intake of the essential amino acids increases the bodys need for the non-essential amino acids either through diet or supplementation

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The process begins with injury to the endothelial cells, which can be caused by several factors, such as hypertension, smoking, and diabetes (119)

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Meanwhile, gut microbiota-derived metabolites with their recent applications, challenges and opportunities their pathways on different disease treatment are focus discussed

Acknowledgements We thank all respondents for their contribution