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This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)

however, mucolytics (acetylcysteine, guaifenesin) or beta blockers [188] can be used if these are insufficient

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The control group received their standard hospital treatment only