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Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M

Its designation permits its use exclusively for in vitro testing and laboratory experimentation

The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

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Neurotrophic Factor Delivery (top right, orange): Administration of trophic molecules like BDNF and CDNF, either via receptor activation (e.g., TrkB) or exosome-based delivery, promotes neuronal survival, synaptic stability, and overall network resilience

The pathology of idiopathic sudden sensorineural hearing loss