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RAS functions as a guanosine diphosphate (GDP)/triphosphate (GTP) binary switch, which controls important signal transduction from activated membrane receptors to intracellular molecules 22 The binary switch is mainly determined by two kinds of regulatory proteins: guanine nucleotide exchange factors (GEFs) such as son of sevenless (SOS) and GTPase-activating proteins (GAPs) such as neurofibromin 1 (NF1) 23

Increased inducible nitric oxide synthase expression in organs is associated with a higher severity of H5N1 influenza virus infection

Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction

May support general energy levels and overall recovery after exercise

Yoo Du-yeol , our role is to help patients make informed decisionsespecially when the treatment may pose long-term risks

doi: 10.1242/jcs.222836 190 Sanchez-MartinP.SaitoT.KomatsuM