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156 This combination of metabolic disturbances creates a vicious cycle of bioenergetic failure, resulting in distal-to-proximal nerve damage and producing the characteristic stockingglove pattern of DPN symptoms

For promoting ciliogenesis, using -helical peptides on plasma-treated polymers has also shown promise by enhancing peptide adsorption, which supports epithelial attachment, tight junction formation and cilia regeneration 96

M., Ellsworth H., and Zwank M

The fasting intervention significantly increased the activity of liver enzymes, the concentration of UA, FR, C, -HB (p 0.05

Of particular importance is the maintenance of redox state achieved via glutathione reductase (GR) mediated regulation of the ratio of reduced (GSH) and oxidised glutathione (GSSG)