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However, since neither mutations nor risk factors alone fully describe the etiopathogenesis of ALS, a genetime-environment model has emerged, in which the development of ALS is a multistep process, with the genetic background being one of the several triggering factors [18]

Adenoviruses expressing Hmox1 (Ad-Hmox1) were purchased from HanBio (4.010 10 PFU/ml)

doi: 10.4065/73.11.1046 72 DelgrangeEVasiljevicAWierinckxAFranoisPJouanneauERaverotGet al