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The effects of collagen loss include fine lines and wrinkles , a loss of skin elasticity and firmness, greater drooping (jawline, cheeks), slower wound healing, and more visible pores and textural defects

Both aerobic glycolysis and pyruvate metabolism play important roles in fibroblast proliferation, myofibroblast differentiation, and fibrotic tissue alterations [61, 62]

Some patients report a mild warming sensation, slight chest pressure, or digestive fluttering

Glutathione : A potent antioxidant that detoxifies the skin and promotes a radiant complexion

Common challenges include: insufficient statistical power due to small sample sizes

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