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Figure 2C)

Cinnamon stimulates insulin receptors in the body and plays a powerful role in stabilizing blood sugar levels (14)

Of note, GLS1 inhibition causes an elevation of the ROS level and induces GPT2 expression via ATF4, which again implies the importance of ATF4-mediated metabolic adaption during glutamine starvation

Pelosi, L., Mulroy, E., Rodrigues, M

PubMed , Medicine , vol

Additionally, PRDX6 acts as a selenium-binding protein that promotes efficient intracellular selenium utilization, thereby sustaining GPX4 expression and activity and indirectly enhancing resistance to ferroptosis (Ito et al., 2024)