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An increase in oxidative damage in the diabetic kidney may induce apoptosis and contribute to the development of diabetic nephropathy [312, 313, 315]

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de Castro Brs LE, Frangogiannis NG

It has also been demonstrated that NAD + can exacerbate high-fat diet (HFD)-induced lipid accumulation in mice through the SIRT1/AMPK/SREBP-1 signal pathway (Shehata et al

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