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When GPX4 activity diminishes, lipid peroxidation proceeds unimpeded, consequently triggering ferroptosis (22)

Moreover, in the murine inflammatory bowel disease model, a reduction in neutrophil migration was demonstrated through the blockade of the CD128 chemokine receptor (132)

Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan

Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina

Glick, HA