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IDH-mutations and 2HG Pellegatta and collaborators [110] evaluated 2HG production in vivo employing 1 H MRS absolute quantification in mice bearing R132H IDH1-mutated GL261 gliomas

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We investigated such an influence on E GSH [IMS], and assessed whether and how it might be counterbalanced by the connection of the glutathione pools of cytosol and IMS (Figure 5)