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European journal of endocrinology , 139 (5), 552561

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Unlike the postulated NO scavenging or sequestration mechanism of V-B12, Cycob is unable to produce an analogous increase in blood pressure and systemic vascular resistance as seen with V-B12, consistent with the slower kinetics for NO substitution of CN compared with hydroxide.14,60 In summary, V-B12 is likely much more effective than Cycob at binding NO because the substitution kinetics and dissociation constants substantially favour loss of hydroxide compared with CN

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