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doi: 10.1038/s41582-023-00822-1 275 PelvigD

In the functional medicine patient population, it is almost always a consequence of a system that has been under sustained burden: years of nutrient depletion, chronic toxic load, persistent inflammation, dysbiosis, hormonal dysregulation, or unrelenting physiological stress

R.HartmannN.PietschS.et al (2015)

Spoiler reviews are systematically longer and skew negative because they're written by people who needed to vent specifics

H.HanL.et al (2020)