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A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

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At the molecular level, hepatic Gclc or Gclm KO triggers a robust activation of Nrf2 and its target genes in liver (12, 13), indicating increased oxidative stress response, whereas Nrf2 level is not increased in livers with Chac1 overexpression