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A lack of vitamin B12 can often lead to fatigue and weakness due to megaloblastic anemia a blood disorder that causes unusually large red blood cells (megaloblasts) and a lower red blood cell count, which results in a lower supply of oxygen to the body

The effectiveness of treatment will be analysed by examining the therapeutic success achieved in each arm at 8, 26 and 52 weeks, determining the 95% confidence interval for the percentage of patients in each treatment arm whose serum vitamin B12 concentrations become normalised

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Another factor is vapor pressure