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[DOI] [PubMed] [Google Scholar] 156.Ugamraj, H

For 78c, the most important interaction in the active site appears to be a hydrophobic interaction of C4 group and Trp176 and the hydrogen bond between the 2-ketoresidue and the side chain amide of Asp183 [78]

This can lead to numbness and tingling in your hands and feet, mental confusion, weight loss, and generally feeling wiped out and weak, as reported by the Mayo Clinic

Patients with known chronic conditions such as liver disease, kidney disease, or previous cancershould ensure their healthcare team is aware of elevated B12 results, as this may influence monitoring strategies or treatment decisions

It can also affect how genes work in kidney and ovarian cancer

Its involved in approximately 100 vital bodily functions including DNA synthesis, protein conversion, neurological function + fatty acid production