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Description

J Biol Chem 293:1907819091

The overall biosynthetic pathway of isoprostanes involves the formation of arachidonyl radicals and peroxyl radical isomers with endocyclization, forming bi-cycloendoperoxide regiomers reduced to F2-isoprostanes (F2-IsoPs)

Here is what that looks like in practice

In addition, HK2 functions as a molecular switch from glycolysis to autophagy in order to ensure cellular energy homeostasis under starvation conditions 49