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In the MAD cohorts, all subjects but one individual in cohort 8 (210 mg) were positive for ADA at one or more timepoints ( Figure 2B )

1 Introduction Alzheimers disease (AD) is the most common neurodegenerative disease worldwide, affecting approximately 55 million people ( The pathologic hallmarks of AD are beta amyloid (A) plaques and tau neurofibrillary tangles which contribute to neurologic damage characteristic of AD

The molecule is subsequently further galloylated, with the use of other glucogallin molecules as galloyl donors, to form 1, 2, 3, 4, 6-penta- O -galloylglucose