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MT3 regulates intracellular Zn 2+ activity, leading to ROS production regulation via the NRF2, HO-1, and CAT pathways

PD involves the progressive degeneration of dopamine-producing neurons in the substantia nigra, resulting in reduced dopamine neurotransmitter in the striatum as shown in Fig

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Prolonged high doses may reduce zinc levels, as glutathione influences metal ion balance in the body

There is debate regarding thiamines involvement in cancer