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J Eur Acad Dermatol Venereol 33:560567

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After 30 min of ischaemia, mice were sacrificed by cervical dislocation with the occlusion suture left in situ to prevent reperfusion

During pregnancy and lactation, even natural substances can affect: Fetal development Placental function Breast milk composition Since research is limited, no supplement can be declared fully safe unless studied in pregnant or breastfeeding women specifically

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Clearly, including guidance on these aspects of practice within the ACP clinical practice guideline would have had a major effect on the safety and effectiveness of management of gout in primary care