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doi: 10.1037/0278-6133.21.6.531 106 MillerA

72,73 Currently identified lactyl-CoA synthetases include acyl-CoA synthetase short-chain family member 2 (ACSS2) and GTPase-associated propionyl-CoA synthetase-like protein (GTPSCS)

Thus, the excess PyroGlu in a septic patient without an enzymatic deficit in the gamma-glutamyl cycle could be associated with GSH depletion, and therefore excessive oxidative stress and its negative consequences