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Notably, glucose metabolic imbalance contributes to increase the oxidative stress, impairing ATP production, thus providing a hint for the exacerbation of neurodegeneration 25

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The enzyme either hydrolyzes or, in the presence of a co-substrate such as glycyl-glycine, transfers the -glutamate group of glutathione, leaving cysteinyl-glycine [91]

doi:10.3899/jrheum.120989

These bonds dissolve when exposed to the proper wavelength of light, releasing the active substance and enabling highly accurate, on-demand administration (129, 130)