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Unlike niacin, nicotinamide doesnt help treat high cholesterol

The purpose of this study was to determine the impact of the American Academy of Orthopaedic Surgeons (AAOS) clinical practice guidelines on the use of these injections in the United States and determine if utilization differed by provider specialty. A little background: (After new AAOS guidelines were issued that questioned how effective these treatments were: The trend in use of hyaluronic acid injections by orthopedic surgeons and pain specialists decreased with time following the second-edition clinical practice guideline but did not change for primary care physicians or nonoperative musculoskeletal providers

This suggests additional anti-aging and cellular health benefits beyond just metabolic enhancement

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

10.1016/j.scitotenv.2023.164620 113 LiY.TianL.LiS.ChenX.LeiF.BaoJ.et al (2024)

556-559 Clinical evidence shows green tea polyphenols improve endothelial function and become incorporated into LDL particles where they protect against oxidation