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Acyl-CoA synthetase long-chain family member 4 (ACSL4) incorporates long polyunsaturated fatty acids (PUFAs) into membranes and is required for ferroptosis 4,5

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Through a comprehensive analysis of patients who experienced stay-up-late and the establishment of sleep deprivation animal models, we have identified that serum serine levels were also closely related to AMH levels in POI, suggesting that serine deficiency may be a common cause for various POI 62,79

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