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In this sense, some studies suggest that the cytokine storm that is present, especially in more severe COVID-19 patients, may activate the indoleamine 2,3-dioxygenase 1 (IDO-1) enzyme and, consequently, culminate in a drastic reduction of tryptophan, increases in toxic metabolites of the kynurenine pathway, and depression (Bouas et al

Impact of antibiotic use in adult dairy cows on antimicrobial resistance of veterinary and human pathogens: a comprehensive review

ISBN 978-0-7817-4118-7

for 45 weeks

USA, 2007 , 104 , 2265-2270

Although clinical translation remains in its early stages, the gut-brain axis represents a promising, non-invasive, and systems-level target for neuroprotection