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The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

That distinction is important

However, KEAP1 regulates multiple pathways beyond NRF2 60,82 , and the contributions of NRF2 to lipid homeostasis have been reported to be pleiotropic and context-dependent 83

[DOI] [PubMed] [Google Scholar] Mattiroli F, Vissers JH, van Dijk WJet al

L-Glutathione is a naturally occurring tripeptide composed of glutamate, cysteine, and glycine and is present in nearly every cell of the body

C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter