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However, very large VLDL particles cannot be secreted if their diameter exceeds that of the sinusoidal endothelial pores, and this limitation may ultimately result in lipid retention and NAFLD [120]

So the timing of medications is very important for their effective outcome and safety.Few medications need to be taken on an empty stomach, like few thyroid medications, medications for gastritis, some of the anti-tubercular medications, some anti-diabetics, etc., which help in the absorption of medications into the blood.While some medications should be avoided on an empty stomach, such as antibiotics, vitamins, mineral supplements, etc., which might cause gastric irritation/GI intolerance (nausea, vomiting)

10.1002/adhm.202100059 26 GourishettiK.KeniR.NayakP

Sudarshan, S., Sangeeta, S., Sheth, N.R., Roshan, P., Ushir, Y.V., Gendle, R., 2009

Nutrients , 12 (1), 217