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This is consistent with the increased colocalization of mitochondria with p62/SQSTM1 detected in APOE 4/4 fibroblasts (Figure 4C), indicating a possible impaired mitophagy

& Mooney, D

For a closer look at this challenge, see our article on Is Liposomal Glutathione Absorbed

doi:10.3945/ajcn.117.157107 41

Atomic coordinates have been deposited in the Protein Data Bank (PDB) under accession codes 9PMD (OCTN2 inward-facing), 9PDQ (OCTN2 occluded) and 9PFB (OCTN2 ipratropium)