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Pathological astrocytes are distinguished by the expression of a specific marker WD Repeat Domain 49 (WDR49), while immunohistochemistry demonstrated that WDR49-positive astrocytes form clusters that are scattered randomly throughout the cortex of patients with FTD 225,226

Bone length, compact bone substance, spongy bone, tissue mineral density, and the thickness of the cortical bone were evaluated using the computed tomography (120 kV/100 mAs, 0.5 s/0.27 mm, HP53.0)

Abnormalities in selenium metabolism and skeletal development diseases Selenium deficiency is regarded as one of the initiating factors of KBD, which is an endemic osteoarthropathy caused by the premature closure of epiphyseal plate and the impaired skeletal development

For FY 2023, we applied the same methodology finalized in FY 2020, using the historical outlier reconciliation amounts from the FY 2017 cost reports (cost reports with a begin date on or after October 1, 2016, and on or before September 30, 2017)

Physiological roles : transport of nitrogen in a non-toxic form and of the gluconeogenic substrate pyruvate to the liver, thereby shifting the metabolic burden associated with nitrogen disposal and glucose regeneration to the liver

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