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In vitro studies, Jang, G observed a sustained high level of field potentials in the CA1 region by treating hippocampal brain slices with ketamine in vitro, suggesting a long-lasting change in synaptic plasticity [18]

Miyake and coauthors used primary microglial cultures from wild-type and TRPM2-knockout mice to understand how TRPM2 regulates nitric oxide (NO) production [63]

Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J: Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage