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Consequently, erythrocytes rely on de novo glutamate biosynthesis from -ketoglutarate and glutamine to maintain intracellular levels of glutamate

& Groden, J

We will enroll 300 AIS patients at up to 50 sites with baseline NIHSS 4, who can receive study drug within 4.5-24 hours of last known well (LKW), and with evidence of core-penumbra mismatch but not receiving standard of care acute stroke reperfusion therapies, will be eligible