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During the course of the disease, motor neurons in the brain and the spinal cord degrade, causing progressive muscle loss and eventually respiratory failure

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For example, initial T cells have the lowest metabolic efficiency for glutamine metabolism because they only require it for survival, while effector T cells (Teff) that require rapid proliferation have a higher rate of glutamine metabolism, providing them with sufficient macromolecular synthesis materials

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recognition of increased folate requirements is particularly important in women of childbearing age