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In vitro skin penetration test Transdermal experiments were performed using Franz diffusion cells

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Exposure to temperatures above 86F (30C) can cause the active ingredient in Wegovy, semaglutide, to break down and you must discard the pen when exposed to extreme temperatures or direct sunlight

This may help explain why it is little used by health professionals

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Semaglutide works through GLP-1 receptors alone, and Couture Med Spa describes it as "widely recognized for appetite regulation and sustained progress over time," though the practice notes individual results vary and some patients see changes sooner than others