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A polymorphism or variation in the sequence within an ER-response element located in the SELENOS promoter was found to result in reduced SELENOS promoter activity and gene expression (36)

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An example of such an approach also includes the use of hydrogen sulfide (H 2 S)

The released DCA inhibits PDK (a key enzyme in the metabolism of tumor cells), shifting the cancer cells metabolism from aerobic glycolysis to oxidative phosphorylation, aiding in overcoming drug resistance