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The first committed step in biosynthesis of SB flavonols is the formation of naringenin chalcone, the result of the condensation of p -coumaroyl-CoA (originating from L-phenylalanine) with 3 malonyl-CoA units, catalysed by chalcone synthase

S.StagstedL

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The enhanced synergy in the MGMT positive TMZ-resistant model is likely due to the increased activity of T25 compared to TMZ