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In contrast, the excitatory gastric response elicited by hindpaw stimulation was governed by the activation of the vagal efferent nerve, which necessitated the involvement of the brain as its reflex center

Bile acids play an important role in regulating intestinal barrier function, lipid metabolism, and immune response, and their metabolic disorders may lead to impaired intestinal barrier function, promote the production of inflammatory factors, and further affect the pathological process of PD

Li S, Guerin-Deremaux L, Pochat M, Wils D, Reifer C, Miller LE

Unlike prescription medications, most peptides arent highly regulated

Changes in brain metabolite levels across childhood

The defect involves pH-dependent TRPML1-mediated efflux of calcium that activates c-Jun amino-terminal kinase ( JNK)-mediated phosphorylation of dynein intermediate chains, and thereby impedes retrograde motility 19