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Li B, Hao J, Zeng J, Sauter ER

This feature is generally advantageous for avoiding central nervous system-related side effects 165,166

Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: systematic review

Interestingly, chronic supplementation with fucoidan mitigated the downregulation of BDNF-dependent synaptic plasticity by reducing caspase-1-mediated inflammation and substantially improving behavioral deficits associated with caspase-1 overexpression in the hippocampus of mice

Such approaches will enhance its scientific value and clinical potential as a functional food and natural therapeutic agent, while laying a theoretical foundation and shaping a practical framework for its standardized development, global application, and cross-cultural integration into modern medicine