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Mitochondria are responsible for cardiomyocyte death through necrosis and apoptosis in ischaemia/reperfusion 62 , both initiated by the disintegration of mitochondrial membranes

Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, et al

However, due to the side effects reported when using the standard prophylactic medication (antiepileptic drugs, calcium channel inhibitors) [38,39] or abortive therapy, the discovery of substances with a more gentle effect and better tolerance is still required, i.e., causing less side effects [40]

The number of relevant studies on ferroptosis has grown exponentially, with many cancer-related genes and signaling pathways exerting great potential in regulating ferroptosis, and mechanistic studies showing the potential evolutionary origin of ferroptosis

doi:10.1100/tsw.2009.137 Gupta A, Vij G, Sharma S, Tirkey N, Rishi P, Chopra K (2009) Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model

Singh R, Gautam N, Mishra A, Gupta R