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The type of control and study location were identified as sources of high heterogeneity following subgroup analysis

Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial

2017;45(W1):W49-54

Signs of low B12 and food sources Possible signs of low B12 status include persistent tiredness, a sore or smooth tongue, pins-and-needles sensations, low mood and brain fog

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Do not stop prescribed B12 treatment without medical advice, especially if you have documented deficiency or pernicious anaemia