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The kidneys high oxygen demand for blood filtration renders it exquisitely sensitive to redox imbalancean aberration common to both CKD and acute kidney injury (AKI) that, when coupled with iron dysregulation, unleashes ferroptosis: a non-apoptotic, iron-dependent form of regulated cell death driven by iron accumulation, lipid peroxidation, and antioxidant defense impairment (e.g., GPX4/SLC7A11 dysfunction), cascades to which the redox-sensitive kidney is uniquely predisposed

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2a, b) highlights the importance of the bioavailability of cysteine to enable cells to adapt to metabolically challenging conditions, as well as mediating cancer cell survival, tumour growth, metastases formation, resistance to therapy and disease recurrence

S., Zhao, X., Knigsrainer, I., Knigsrainer, A., Balletshofer, B., Machann, J., Schick, F., Fritsche, A., Hring, H

Liver: Anatomy undergoes glycolysis Glycolysis Glycolysis is a central metabolic pathway responsible for the breakdown of glucose and plays a vital role in generating free energy for the cell and metabolites for further oxidative degradation

However, EETs are rapidly metabolized by sEH